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KMID : 0043319950180030164
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Archives of Pharmacal Research
1995 Volume.18 No. 3 p.164 ~ p.168
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Cytotoxicities of Ginseng Saponins and their Degradation Products against some Cancer Cell Lines
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Baek Nam-In
Kim Dong-Seon
Lee You-Hui
Park Jong-Dae
Lee Chun-Bae
Kim Shin-Il
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Abstract
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In order to elucidate the cytotoxicity-structure correlation of ginseng-derived components, several prosapogenins and sapogenins were prepared from Korean red ginseng (Panax ginseng) saponins by acid hydrolysis or alkaline cleveage, and their chemical structures were identified by a combination of spectral and physical methods. Some of these degradation products showed the cytotoxic activities against various cancer cell lines, A549, SK-OV-3, SK-Mel-2, P388, L1210 and K562. The significant difference in cytotoxicity between stereoisomers was not found and the activity was inversely proportional to the number of sugars linked to sapogenins. Diol-type prosapogenins and sapogenins showed higher cytotoxicity than triol-type ones.
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KEYWORD
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Panax ginseng, Cytotoxicity, Ginsenosides, Prosapogenins, Sapogenins, Structure-cytotoxicity Relationship
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